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Adams, David S.
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Major Qualifying Projects
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Worcester Polytechnic Institute
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Yeast two-hybrid of PIE-1 in C. elegans
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Use of HIV-1 2-ltr circle sequences as a predictor of drug-induced mutations
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Upregulation of Neuronal Growth Genes During a Therapy for Rat Spinal Cord Injury
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Understanding the function of SFRP-1, a Wnt antagonist, in the development of murine skeletal tissue
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Transforming growth factor- and prostate cancer
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The role of XRCC3 in homologous recombination
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The role of Flt3/Flk2 in B cell development
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The Presence of DNA-binding protein LSF in a complex that binds to the switch region of immunoglobulin heavy chain gene gamma 3
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The effects of circadian rhythm and low-dose irradiation (100cGy) on murine bone marrow transplantation
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The effect of a dominant-negative RIP-K45A on TNF-stimulated L929 cells
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The Activator protein-1 upregulated by neurotrophic peptides NMI-9236 and NMI-8933 is capable of transcriptional trans-activation
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Syntaxin 1A functions as the sufficient T-SNARE for spontaneous fusion of bovine NSG to a planar lipid bilayer
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STATs are involved in T-cell development downstream of IL-7 receptor
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Small peptide substitutes for full-length neurotrophic factors
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Small peptide substitutes for full-length ependymin neurotrophic factor up-regulate SOD, which is part of the cell's natural response to anoxia
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Small peptide substitutes for full-length ependymin neurotrophic factor up-regulate SOD
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SHP2 tyrosine phosphatase association with endothelial plasma membranes is regulated by cholesterol
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Sequence analysis of CP and NCP HIV-1 clones
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Selective amplification of cryopreserved human umbilical cord blood stem cells
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Roll of factors and interacting proteins in Cbfa1 function
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Ribozyme viral infection of Hct116 cells
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Rescue of a nonfunctional Newcastle disease hemagglutinin-neuraminidase protein by mutation of key residues residing at the dimer interface
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Regulation of Runx genes during mesenchymal chondrogenesis
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Regulation of osteoblast differentiation by Msx2 and Dix3 homeodomain transcription factors
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Protein kinase assay development and compound characterization using HTRF technology
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Prohormone convertase 2 as a biomarker for neuroendocrine lung tumors -- detection of gene products in PreservCyt solutions
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Production of biologically active CDK inhibitors p21 and p27 as TAT-fusion proteins
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Production of antibodies against specific neurotransmitter receptors
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Production of a putative mouse homolog for Protein AS160 and its use for antibody formulation for studying GLUT4 trafficking in adipocytes
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Production of a NGF-TV A fusion protein for the potential targeting of an ALV-pseudotyped lentivirus to neuronal cells
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Post-operative pain
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Peptides mimicking neurotrophic factors effective in treating neurodegenerative disorders upregulate anti-oxidative enzymes.
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Nuclear import of HIV-1 -- optimizing siRNA techniques
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Neurotrophic peptides that are therapeutic for strokes in a rat model upregulate enzymes which reduce oxidative stress in various tissues
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Neuronal-like differentiation of human umbilical cord blood stem cells
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Mutational analysis of the neuraminidase activity of the Newcastle Disease HN protein
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Mutational analysis of the HR2 lysine rich strip in the Newcastle disease virus fusion protein
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Movement of the inactivating chromosome to the heterochromatic compartment is coincident with the irreversibility of the inactivation process
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Molecular exchange of E. coli 0157:H7 shiga toxin subunits
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Mitochondrial proteins in mouse tissues
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Mechanism of PMP24 gene silencing in a PC3 prostate cancer cell line
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Ischaemic preconditioning enhances postischaemic recovery in the rat heart
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Investigation of the effect of GLA and ajulemic acid on the production of MMP-1, MMP-3, and MMP-9 in synovial fibroblasts
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Investigation of HN protein function during paramyxovirus infection using site-directed mutagenesis
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Interaction of the human papillomavirus E2 protein with CHLr1
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Interaction and phosphorylation of Relish mutants with the Drosophila IkB kinase complex
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In-situ hybridization in PreservCyt solution using PNA probes
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Inhibition of iNOS helps prevent hearing loss in a guinea pig model of Meniere's disease
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Immunoregulation of autoreactive CTLA-4 T cells in vivo
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Immobilization of Sarcosine Oxidase for use in creatinine biosensors
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Identification of three Drosophila melanogaster GABA-B DNA clones
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Glycoprotein suicide in the proteasome
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Genotype analysis of HIV-1 isolated from an individual with long term nonprogressive infection
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Expression profiling of interleukin-18 activity using cDNA microarray technology
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Expression of survivin using SFV and analysis of phosphorylation site mutagenesis
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Expression of histones H2A, H2B, H3, H4 and Cse4 in an E. coli expression system
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Expression and purification of SDF1- for analysis and evaluation of chemotactic response in cancer cells
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Exploring the use of methylation-specific PCR for diagnosis of cervical and breast cancer in samples form the ThinPrep? Pap Test (TM) collection vial
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Exploration of the Role of Negative Elongation Factor on Tat Transactivation using siRNAs
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Evaluation of immune response raised in rabbits by immunization with HIV DNA vaccines
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Estrogen receptor (ER-) in human prostate cancer cells
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Effects of low protein diet on gene expression using microarray analysis
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Effect of rosiglitazone on 3T3-L1 adipocyte formation
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Discovery of FK506-sensitive and FK506-insensitive genes for use in future clinical trials of novel immunosuppressant compounds
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Differential gene expression in a rheumatoid arthritis mouse model
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Differences in the gene expression of osteopetrotic toothless (tl) rats, colony stimulating factor 1 (CSF-1) treated tl rats, and their normal littermates as determined by differential display
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Diabetes research -- ART2 subclone design and protein expression
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Development of type-specific assays for detecting human papillomavirus in preserved pap smear samples
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Development of components for a green fluorescent protein-based assay for the detection of dengue virus
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Development of a cell lysis assay for natural killer cells
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Decreased expression of stem cell factor in amplified human umbilical cord fractions containing hematopoietic stem cells
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Cytokine production in a rat model of diabetes in response to treatment with poly IC
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Creation of stable transfectants expressing HLA Alleles thought to influence Dengue Disease severity
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Construction of a d-rR male genomic library
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Constitutive tear proteins as possible substrates for a novel pseudomonas protease
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Conjugating a Neurotrophic Peptide to Blood-Brain-Barrier Carrier DHA Increases its Activity for Upregulating Therapeutic Enzymes SOD, Catalase and GPX
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Cloning and expression of salmonella secreted virulence protease SipB
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Characterization of a novel gene in a transgenic mouse model of Huntington's disease
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Biliary excretion in nonhuman primates -- model validation of an implantable catheter system
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Betafectin immunomodulator increases the activities of JNK and IKK kinases and increases the nuclear translocation of AP-1 in macrophage cells
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Apoptosis induced by ajulemic acid in isolated human lymphocytes
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Apoptosis in a MPTP Parkinson's disease mouse model
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Analysis of tissue-specific MDM2 loss during murine embryogenesis
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Analysis of Cytokine mRNA expression during the expansion of stem cell populations from human cord blood
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Analysis of a commercially available ReliaGene Y-STR kit for DNA fingerprinting
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An evaluation of lipid-lowering therapy in CABG patients at UMass Memorial Hospital
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Amplification and cloning of gag and env genes from a long term non-progressor HIV-1 patient
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a-lipoic acid effect on oxalate damage in LLC-PK cells
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Alanine scan mutagenesis in CDR3 of 125-2H
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A mechanistic study of the inhibition of beta amyloid production by protease inhibitors in a whole cell model
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A Genetically engineered second-generation clot dissolver containing uPA-B chain fused to factor XI is active in plasminogen activator assays
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Lung Levels of Neutrophil-Related Chemokines S100A8 and CXCL5 Do Not Correlate With Mycobacterium tuberculosis Levels in 8 Mouse Strains
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B-Crystallin-Mediated Rescue of Centriolin Depletion-Induced Cell Death in Retinal Pigment Epithelial Cells
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A Down Syndrome iPS Cell Line Expressing XIST as a Model For Studying Human Chromosome Inactivation
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A Functional Study of the IMPAS Family of Proteins
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A GAIN OF FUNCTION MUTATION IN THE P/Q TYPE VOLTAGE GATED Ca2+ CHANNEL, UNC-2, STIMULATES ACETYLCHOLINE RELEASE IN CAENORHABDITIS ELEGANS
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A Novel Role of the p53 Tumor Suppressor Pathway in Maintaining Glucose Homeostasis
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A Novel Technique for the Expression and Purification of HIV-1 VIF Co-factor APOBEC3G
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ACTIVATION OF MACROPHAGES IN VIVO BY GLYCAN LNFPIII
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Alphav Beta6 Integrin Expression in Inflamed & Malignant Prostate
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