Index Catalog // Digital WPI

Microfluidic High-Throughput Methods for the Induction and Characterization of Repeatable, Titratable Traumatic Neural Injury in the Nematode Caenorhabditis elegans

Keyword:: Neural Imaging, TRPV4, C. elegans, Traumatic Brain Injury, and Microfluidics
Creator:: White, Hamilton
Advisor:: Albrecht, Dirk
Publisher:: Worcester Polytechnic Institute
Date Created:: 2023-12-08
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

From Farm to Lab: The Potential of Decellularized Plant Leaves for Sustainable Meat Production

Keyword:: Skeletal Muscle, Cultured Meat, Decellularization, Cellular Agriculture, and Lab-grown Meat
Creator:: Jones, Jordan
Advisor:: Gaudette, Glenn and Dominko, Tanja
Publisher:: Worcester Polytechnic Institute
Date Created:: 2023-12-13
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Engineered blood vessels with spatially distinct regions for disease modeling

Keyword:: smooth muscle, bioreactor, microsphere, tissue engineered blood vessel, and disease modeling
Creator:: Strobel, Hannah A.
Advisor:: Rolle, Marsha Whitney
Publisher:: Worcester Polytechnic Institute
Date Created:: 2018-04-24
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

INVESTIGATING THE ROLE OF APOPTOSIS IN CALCIFICATION OF THE AORTIC VALVULAR INTERSTITIAL CELLS

Creator:: Jebeli, Mahvash
Advisor:: Billiar, Kristen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2022-12-15
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Applications of Deep Learning in Brain Injury Biomechanics and Spine Image Registration

Keyword:: Spine Image Registration, Image-guided Surgery, Concussion, Deep Learning, and Brain Injury
Creator:: Wu, Shaoju
Advisor:: Ji, Songbai
Publisher:: Worcester Polytechnic Institute
Date Created:: 2022-08-03
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Characterization and Functionalization of Lyophilized Silk Scaffolds for Use in 3D In Vitro Disease Modeling

Keyword:: Biomaterials, Kidney Cancer, Tissue Engineering, and Liver Disease
Creator:: Abbott, Alycia
Advisor:: Coburn, Jeannine M
Publisher:: Worcester Polytechnic Institute
Date Created:: 2021-07-16
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Applications of Machine Learning in Real-time Brain Tissue Strain Estimation

Keyword:: Concussion, Brain Injury, Convolutional Neural Network, Deep Learning, and Finite Element
Creator:: Ghazi, Kianoosh
Advisor:: Ji, Songbai
Publisher:: Worcester Polytechnic Institute
Date Created:: 2021-08-10
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Generation and Dissemination of a Mesenchymal Stem Cell-Derived Functional Smooth Muscle Tissue

Keyword:: disease model, tissue engineering, mesenchymal stem cells, cryopreservation, and smooth muscle cells
Creator:: Grosha, Jonian
Advisor:: Rolle, Marsha Whitney
Publisher:: Worcester Polytechnic Institute
Date Created:: 2021-08-22
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Effects of Exoskeleton Walking Therapy in the Distal Femur and Proximal Tibia in Individuals with Chronic Spinal Cord Injury

Keyword:: Biomechanics, Bone adaptation, and Exoskeleton
Creator:: Mattson, Nicole E.
Advisor:: Troy, Karen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2021-04-29
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Mechanical Regulation of Cell Death

Creator:: Goldblatt, Zachary
Advisor:: Billiar, Kristen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2020-11-02
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Defining the Multiscale Relationship between Subject-Specific Bone Strain and Structural Adaptation in the Distal Radius of Women

Keyword:: Quantitative Computed Tomography (QCT), Finite Element (FE), High Resolution Peripheral Quantitative Computed Tomography (HRpQCT), Distal Radius, Exercise, and Bone Adaptation
Creator:: Mancuso, Megan E
Advisor:: Troy, Karen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2020-08-07
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Tuning the Biophysical and Biochemical Cues of Fibrin Microthread Scaffolds Towards the Treatment of Volumetric Muscle Loss

Keyword:: tissue engineering, fibrin, skeletal muscle regeneration, biomaterials, volumetric muscle loss, and microthreads
Creator:: Carnes, Meagan E.
Advisor:: Pins, George D
Publisher:: Worcester Polytechnic Institute
Date Created:: 2020-09-29
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Cell-Derived Extracellular Matrix Scaffolds Developed using Macromolecular Crowding

Keyword:: macromolecular crowding, cell-derived matrices, Hyaluronic Acid, and extracellular matrix
Creator:: Shendi, Dalia M
Advisor:: Rolle, Marsha Whitney
Publisher:: Worcester Polytechnic Institute
Date Created:: 2019-08-07
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Machine Learning Pipelines for Deconvolution of Cellular and Subcellular Heterogeneity from Cell Imaging

Keyword:: Cell Migration, Hologram Imaging, Machine Learning (Deep Learning), Time Series Analysis, and Cell Heterogeneity
Creator:: Wang, Chuangqi
Advisor:: Lee, Kwonmoo
Publisher:: Worcester Polytechnic Institute
Date Created:: 2019-08-12
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Portable Bioimpedance System for Early Detection and Prevention of Pressure Injuries

Keyword:: Ulcer, Sensor, Pressure, Bioimpedance, Detection, and Injury
Creator:: Harvey, Joshua R
Advisor:: Mendelson, Yitzhak
Publisher:: Worcester Polytechnic Institute
Date Created:: 2019-09-18
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Development of automated analysis methods for identifying behavioral and neural plasticity in sleep and learning in C. elegans

Keyword:: Associative Learning, C. elegans, Neural Plasticity, Neural Imaging, Microfluidics, and Sleep
Creator:: Lawler, Daniel E
Advisor:: Albrecht, Dirk
Publisher:: Worcester Polytechnic Institute
Date Created:: 2019-12-10
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Magnetic Resonance Imaging of Neural and Pulmonary Vascular Function

Keyword:: MRI Vascular Stroke Pulmonary Neural
Creator:: Walvick, Ronn P
Advisor:: Helmer, Karl G. and Albert, Mitchel
Publisher:: Worcester Polytechnic Institute
Date Created:: 2010-08-29
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Towards the Fabrication of a Fibrin Based Vascular Network

Keyword:: Vascular Engineering, Fibrin, and Vasculature
Creator:: Santos, Johanna Eleanor
Advisor:: Pins, George D
Publisher:: Worcester Polytechnic Institute
Date Created:: 2018-08-16
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Mechanical Regulation of Apoptosis and Calcification within Valvular Interstitial Cells

Keyword:: calcification, apoptosis, calcific aortic valve disease, aortic valvular interstial cells, and traction force microscopy
Creator:: Cirka, Heather Ann
Advisor:: Billiar, Kristen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2016-04-28
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

An Image-Based Method to Measure Joint Deformity in Inflammatory Arthritis

Keyword:: HRpQCT, method, non-linear surface transformation, CT, Imaging, inflammatory arthritis, MCP, and coherent point drift
Creator:: Henchie, Travis F
Advisor:: Troy, Karen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2018-04-26
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Automated whole-organism functional screening technologies and neurological disease models in C. elegans

Keyword:: Assay systems, C. elegans, Neurological disease, Biomedical engineering, and Neuroscience
Creator:: Lagoy, Ross Charles
Advisor:: Albrecht, Dirk
Publisher:: Worcester Polytechnic Institute
Date Created:: 2018-04-26
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Changes in Passive and Dynamic Mechanical Environments Promote Differentiation to a Contractile Phenotype in Vascular Smooth Muscle Cells

Keyword:: smooth muscle cell, 3D culture, cell-derived matrix, Vascular Tissue Engineering, and phenotype
Creator:: Reidinger, Amanda Zoe
Advisor:: Rolle, Marsha Whitney
Publisher:: Worcester Polytechnic Institute
Date Created:: 2015-04-29
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

An Affordable Portable Obstetric Ultrasound Simulator for Synchronous and Asynchronous Scan Training

Keyword:: Ultrasound, Simulation, Education, and Obstetric
Creator:: Liu, Li
Advisor:: Pedersen, Peder C.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2016-01-13
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Engineering the Keratinocyte Microenvironment: Harnessing Topography to Direct Cellular Function

Keyword:: dermal–epidermal junction, keratinocyte function, microtopography, and tissue engineered skin
Creator:: Clement, Amanda Lynn
Advisor:: Pins, George D
Publisher:: Worcester Polytechnic Institute
Date Created:: 2015-01-12
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Characterization and Compensation of Hysteretic Cardiac Respiratory Motion in Myocardial Perfusion Studies Through MRI Investigations

Keyword:: Emission tomography, Cardiac Imaging, Respiratory Motion, Modeling Hysteresis, and MRI
Creator:: Dasari, Paul Krupaker Reddy
Advisor:: King, Michael A and Mendelson, Yitzhak
Publisher:: Worcester Polytechnic Institute
Date Created:: 2014-04-24
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Neuronal Correlates of Diacritics and an Optimization Algorithm for Brain Mapping and Detecting Brain Function by way of Functional Magnetic Resonance Imaging

Keyword:: fMRI, Neuroimaging, Optimization, Diacritics, and Brain Mapping
Creator:: Bourisly, Ali Khaled
Advisor:: Sotak, Christopher H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2011-04-14
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Investigation of the Biological and Physicochemical Properties of Bacillus anthracis Spores during Germination, Virulence, and Killing

Keyword:: Bacillus anthracis, cytokine, Anthrax, spores, and germination
Creator:: Pinzon-Arango, Paola A.
Advisor:: Camesano, Terri Anne
Publisher:: Worcester Polytechnic Institute
Date Created:: 2012-01-11
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Mechanical Activation Of Valvular Interstitial Cell Phenotype

Keyword:: stretch, VICs, stiffness, myofibroblast, and transforming growth factor beta
Creator:: Quinlan, Angela
Advisor:: Billiar, Kristen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2012-08-20
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Cell Printing: A novel method to seed cells onto biological scaffolds

Keyword:: stem cell therapy, Bioprinting, Fibrin, cell therapy, and Cell printing
Creator:: Kanani, Chirantan
Advisor:: Gaudette, Glenn R.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2012-04-26
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Comparison of Alternative Rigid Sternal Fixation Techniques

Keyword:: Osteoporosis, malunion, Sternum, and Rigid Fixation
Creator:: Dieselman, John Conrad
Advisor:: Billiar, Kristen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2012-01-12
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Conditioning of Mesenchymal Stem Cells Initiates Cardiogenic Differentiation and Increases Function in Infarcted Hearts

Keyword:: cardiomyoplasty, cardiac mechanical function, stem cell differentiation, and Mesenchymal Stem Cells
Creator:: Guyette, Jacques Paul
Advisor:: Gaudette, Glenn R.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2012-01-16
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Modifying and Measuring the Stiffness of a Regenerative Cardiac Scaffold In Vitro

Keyword:: myocardial infarction, Ascorbic Acid, Dacron, membrane inflation, Veritas, HDM, Fibroblasts, UBM, and heart
Creator:: Filipe, Daniel V
Advisor:: Gaudette, Glenn R. and Rolle, Marsha Whitney
Publisher:: Worcester Polytechnic Institute
Date Created:: 2010-12-01
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Evaluation of the Effects of Hyperbaric Dive Environments on the Autonomic Nervous System Using Principal Dynamic Mode Analysis

Keyword:: principal dynamic mode, decompression sickness, SCUBA dive, heart rate variability, hyperbaria, and autonomic nervous system
Creator:: Bai, Yan
Advisor:: Chon, Ki H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2011-08-11
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Spatiotemporal Organization of Atrial Fibrillation Using Cross-Bicoherence with Surrogate Data

Keyword:: cross-bicoherence, atrial fibrillation, cross-bispectrum, high order spectral analysis, cardiac electrophysiology, and surrogate data
Creator:: Jaimes, Rafael
Advisor:: Chon, Ki H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2011-05-19
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

MRI Contrast Agent Studies of Compartmental Differentiation, Dose-dependence, and Tumor Characterization in the Brain

Keyword:: contrast agent, glioma, signal decay, dose dependence, manganese, brain, compartmental differentiation, diffusion, tumor, and Magnetic Resonance Imaging
Creator:: Shazeeb, Mohammed Salman
Advisor:: Gaudette, Glenn R. and Sotak, Christopher H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2010-12-12
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

In vivo characterization of respiratory forces on the sternal midline following median sternotomy

Keyword:: fixation, forces, device evaluation, and Sternum
Creator:: Pai, Shruti
Advisor:: Billiar, Kristen
Publisher:: Worcester Polytechnic Institute
Date Created:: 2005-08-30
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Delivering Stem Cells to the Heart

Keyword:: microthreads, heart attack, hMSC, and myocardial infarction
Creator:: Fakharzadeh, Michael
Advisor:: Gaudette, Glenn R.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2010-05-03
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Designing Bioengineered Skin Substitutes Containing Microfabricated Basal Lamina Analogs to Enhance Skin Regeneration

Keyword:: fibronectin, bioengineered skin substitutes, microenvironment, and keratinocytes
Creator:: Bush, Katie Ann
Advisor:: Pins, George D
Publisher:: Worcester Polytechnic Institute
Date Created:: 2009-01-29
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Investigating the effects of cranberry juice on the physicochemical properties of Escherichia coli for the prevention of urinary tract infections

Keyword:: proanthocyanidins, fimbriae, and Bacterial adhesion
Creator:: Pinzon-Arango, Paola A.
Advisor:: Camesano, Terri Anne
Publisher:: Worcester Polytechnic Institute
Date Created:: 2008-01-09
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Fibrin Microthreads Promote Stem Cell Growth for Localized Delivery in Regenerative Therapy

Keyword:: infarct, myocardium, microthreads, human mesenchymal stem cells, and Fibrin
Creator:: Murphy, Megan K
Advisor:: Pins, George D, Gaudette, Glenn R., and Rolle, Marsha Whitney
Publisher:: Worcester Polytechnic Institute
Date Created:: 2008-09-02
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Magnetic Resonance Imaging of the Rat Retina

Keyword:: Magnetic Resonance Imaging, Mn54-autoradiography, Manganese Enhanced MRI, High-Resolution MRI, RCS Rat, Retinal Degeneration, Rat Retina, and Blood Volume Imaging
Creator:: Bhagavatheeshwaran, Govind
Advisor:: Sotak, Christopher H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2008-04-16
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Osmotic- and Stroke-Induced Blood-Brain Barrier Disruption Detected by Manganese-Enhanced Magnetic Resonance Imaging

Keyword:: blood-brain barrier, osmotic shock, manganese-enhanced MRI, and rat brain
Creator:: Bennett, David G
Advisor:: Sotak, Christopher H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2007-08-17
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Design of a Noninvasive System for the Evaluation of Collagen Scaffolds Using MRI

Keyword:: histology, implant, MRI, and Biomaterials
Creator:: Howes, Stuart C
Advisor:: Pins, George D
Publisher:: Worcester Polytechnic Institute
Date Created:: 2007-05-25
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Collagen and Fibrin Biopolymer Microthreads For Bioengineered Ligament Regeneration

Keyword:: microthread, collagen, Ligament, thread, fiber, Fibrin, FGF2, Tissue Engineering, fibroblast, tissue regeneration, and ACL
Creator:: Cornwell, Kevin G.
Advisor:: Pins, George D
Publisher:: Worcester Polytechnic Institute
Date Created:: 2007-05-04
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

In vivo monitoring of collagen-sponge remodeling using MRI

Keyword:: collage remodelling, MRI, and in vivo
Creator:: Kandasamy, Sivakumar P
Advisor:: Sotak, Christopher H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2007-03-26
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

The Impact of Using an Obstacle Sensing System in the Power Wheelchair Training of Children with Disabilities

Keyword:: mobility training, power wheelchair, and obstacle sensing
Creator:: Manrique, Lisette M
Advisor:: Hoffman, Allen H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2005-05-03
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

NMR Characterization of Pathological Disease States: Monitoring Response to Single-Dose Radiotherapy in a RIF-1 Tumor Model and the Role of Spreading Depression in the Evolution of Ischemic Stroke

Keyword:: spreading depression, diffusion, stroke, RIF-1, multispectral analysis, and MEMRI
Creator:: Henning, Erica C.
Advisor:: Sotak, Christopher H.
Publisher:: Worcester Polytechnic Institute
Date Created:: 2005-04-22
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

A Computer-Based Cascaded Modeling and Experimental Approach to the Physical Characterization of a Clinical Full-Field Mammography System

Keyword:: screen-film, mammography, and linear cascade model
Creator:: Ved, Hetal R
Advisor:: Karellas, Andrew
Publisher:: Worcester Polytechnic Institute
Date Created:: 2002-09-20
Resource Type:: Thesis
Degree:: MS
Unit (Department):: Biomedical Engineering

Design and Performance of a Localized Fiber Optic, Near-Infrared Spectroscopic Prototype Device for the Detection of the Metabolic Status of “Vulnerable Plaque”: in-vitro Investigation of Human Carotid Plaque

Keyword:: tissue lactate, vulnerable plaque, atherosclerosis, optical spectroscopy, and tissue pH
Creator:: Khan, Tania Nur
Advisor:: Peura, Robert A., Soller, Babs R., and Tuft, Richard
Publisher:: Worcester Polytechnic Institute
Date Created:: 2003-01-08
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

Design and Characterization of a High-resolution Cardiovascular Imager

Keyword:: Detector design and characterization and Modulation Transfer Function, Digital Fluoroscopy,
Creator:: Vedantham, Srinivasan
Advisor:: Karellas, Andrew
Publisher:: Worcester Polytechnic Institute
Date Created:: 2002-06-07
Resource Type:: Dissertation
Degree:: PhD
Unit (Department):: Biomedical Engineering

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