TY - RPRT A1 - Beaurivage, Scott AB - Rac1 is a member of a family of small GTPases that are primarily responsible for cellular motility and morphology. Activation of Rac1 by Rac-specific guanine nucleotide exchange factors (GEFs) is thought to be important for the metastasis of cancer cells. The scope of this project was to synthesize a minimal extended peptide sequence that would block interaction between Rac1 and the Rac1-specifice exchange factor GEF-H1. Inhibition of Rac1 activation by Rac-specific GEFs would be a useful tool for the study of Rac-mediated cellular processes and may ultimately result in cancer therapeutics. DA - 2006/04/26 DB - Digital WPI DP - Worcester Polytechnic Institute ID - E-project-042606-114459 L1 - https://digital.wpi.edu/show/qn59q551x LK - https://digital.wpi.edu/ PB - Worcester Polytechnic Institute PY - 2006 T1 - Specific Inhibition of Rac1 Activation UR - https://digital.wpi.edu/show/000001359 ER -