The following paper shows a novel way to deliver a cellular solution to thick tissue by combining the use of a standard laboratory tool, the P-1000 pipette, with an up-and-coming technology, microneedles. Our team worked to standardize a decellularization protocol using Triton X-100 to be used on chicken breast. The team also worked to develop a microneedle prototype that could deliver cells to these decellularized tissues. Using the decellularized scaffolds and the device prototype, testing procedures were conducted to determine the device's effectiveness. Histological analysis was used to verify that the device was successfully delivering cells and that these cells were able to disperse within the decellularized tissue.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Maloy, Dana
• Garrow, Katrina
• Villamizar, Juan
• Troop, Isabella

Publisher

• Worcester Polytechnic Institute

Identifier

• 65151
• E-project-042822-112339

Advisor

• Ambady, Sakthikumar

Year

• 2022

Date created

• 2022-04-28

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright