Characterizing microglial interactions with cortical neurons during development of the healthy brain
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open in viewerRecently, microglia were found to have roles in synaptic pruning, synaptic stripping, and neuroprotection. Through these studies an interesting phenomenon of microglia making soma-to-soma contact, “hugging”, with cortical neurons was observed. The goal of this study was to use transgenic mice to define hugging behavior throughout post-natal neuronal development. Specifically, how many soma-to-soma contacts were being made by microglia and what types of neurons were being contacted. I further investigated the role of AMIGO1, a cell adhesion molecule found in neurons and glia, in hugging behavior. Understanding normal microglial-neuronal interactions in the healthy brain is relevant to many neurodevelopmental diseases.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042717-124306
- Advisor
- Year
- 2017
- Sponsor
- Date created
- 2017-04-27
- Resource type
- Major
- Rights statement
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Frederick_Gergits_MQP_Report.pdf | Public | Download |
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