Muscle myopathies cause high fatality rates and lack effective clinical drug treatments. Currently, there are no in vitro skeletal muscle tissue models that precisely mimic native human muscle morphology and function due to a lack of maturation. Animal models also fail to provide clinically-relevant data due to a lack of genetic homology to humans. Therefore, drug efficacy cannot be accurately tested pre-clinically before human clinical trials. To improve in vitro skeletal muscle tissue maturation, a device was designed to mechanically stimulate skeletal muscle tissue. The device effectively provided a morphological difference in C2C12 myoblast as well as primary human myoblast derived tissue constructs, with less necrosis and greater myofiber alignment compared to the static constructs.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Scuderi, Gaetano J.
• Teed, Craig S.
• Biliouris, Timothy J.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042616-161408

Advisor

• Page, Raymond L.

Year

• 2016

Date created

• 4016-04-26

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Source

• E-project-042616-161408

Rights statement

• In Copyright

Last modified

• 2024-05-13