The student worked with Pfizer Inc. to study the feasibility of an immobilized enzyme in the preparation of an intermediate to Glasdegib, a Phase I clinical SMO inhibitor that has shown promise in the inhibition of tumor growth for human colorectal and pancreatic cancers. The project resulted in an optimization of one immobilized resin based on the activity of the enzyme, enzyme stability in organic solvents, and reuse of the biocatalyst as well as apreliminary scale-up study utilizing AspenPlus.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Galati, Corin A.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042616-191118

Advisor

• Brodeur, Drew R.
• Kmiotek, Stephen J.

Year

• 2016

Sponsor

• Pfizer Inc.

Date created

• 4016-04-26

Resource type

• Major Qualifying Project

Major

• Interdisciplinary

Source

• E-project-042616-191118

Rights statement

• In Copyright

最新修改

• 2024-05-13