Student Work

MdmX Regulates Mitotic Spindle Polarity of Human Breast Cancer Cells

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The proteins Mdm2 and MdmX are critical negative regulators of the tumor suppressor p53 and, when overexpressed, they function as oncogenes. However, recent research has shown MdmX to function as a tumor suppressor in p53-deficient mice and to increase genome stability in p53-deficient mouse cells. This project investigates the effect of MdmX on genomic stability in human breast cancer cells. The results show a correlation between MdmX and a decrease in multipolar spindles, along with an increase in chromosome number. These findings could provide a fundamental understanding of the role of genomic stability in human cancer.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-042213-174903
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Year
  • 2013
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Date created
  • 2013-04-22
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Dernière modification
  • 2023-11-07

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