The purpose of this MQP was to use a subtraction hybridization technique to assay gene products upregulated in an arthritic mouse model. The feasibility of using this complex technique was verified on Jurkat cells treated to upregulate several genes, including those for interferon-gamma and interleukin-2. Several T-lymphocyte activation-related genes were identified by cloning and sequencing. This technique applied to the arthritic model found several inflammation-related genes upregulated.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Timm Al-Beik, Jennifer Elise

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D080M

Advisor

• Adams, David S.

Year

• 2000

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright