Greyhounds have been found to have decreased rates of clearance of the anesthetic propofol, in addition to a longer recovery period, as compared with other breeds of dog. Clearance of propofol involves hydroxylation, which has been shown to be mediated by cytochrome P-450 (CYP), a microsomal mixed-function oxidase system. Greyhound, beagle, and mixed-breed microsomal liver samples were quantitatively analyzed by the Western Blot technique for a variety of CYP isoforms. The amount of this drug-metabolizing enzyme present in greyhounds at least partially explains the pharmacokinetic differences.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Samuels, Eryn J.

Publisher

• Worcester Polytechnic Institute

Identifier

• 05D423M

Advisor

• Wobbe, Kristin K.

Year

• 2005

Date created

• 2005-01-01

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright