The gene mig-10 in C. elegans affects cell migration, axon guidance, and process outgrowth. mig-10 shows sequence homology to signal transduction proteins that interact with the rac GTPases. In order to determine if mig-10 have any interaction with the rac genes, mig-10 double mutants with a number of rac pathway genes were constructed. All double mutants with each rac gene showed a more severe defect in process outgrowth than the single mutant mig-10(ct41), while only some rac gene double mutants had a greater defect in embryonic migration. These results suggest mig-10 interacts with the rac genes.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Tse, Sze - Wah

Publisher

• Worcester Polytechnic Institute

Identifier

• 03D157M

Advisor

• Ryder, Elizabeth F.

Year

• 2003

Date created

• 2003-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright