HIGHER LEVELS OF ER STRESS IN DIABETES-PRONE RATS PLAYS A ROLE IN APOPTOTIC SIGNALINGPublic
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Biobreeding diabetes-prone (BBDP) rats exhibit a severe T cell lymphopenia, which may be linked to cellular stress. Expression of GRP78, an ER stress regulatory protein, was examined in various T cell populations of BBDP and BioBreeding diabetes-resistant rats (BBDR). Flow cytometry analysis revealed increased ER stress in all mature populations of T cells examined from the BBDP rat, but not in the immature thymocytes. These results suggest that increased ER stress in BBDP rats may play a role in apoptotic signaling that leads to T cell lymphopenia.
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