Deep tissue injuries, such as severe burns and volumetric muscle loss result in significant function loss from inadequate tissue regeneration. Current treatment options are not optimal. There is a need for a device to recellularize thick tissue scaffolds to promote tissue regeneration in large tissue injuries. This project was aimed at developing a micro/nanoneedle system capable of delivering precise volumes of cell suspension to decellularized tissue scaffolds at least one centimeter thick. The final device consists of two parts: 30g needles and a cell suspension reservoir attached to a motor-driven syringe pump. Verification and validation testing showed that the device can efficiently deliver cell suspension to decellularized tissue up to one centimeter deep.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• McLaughlin, Keri
• Ormerod, Julia
• Langille, Marissa
• Netto, Jessica

Publisher

• Worcester Polytechnic Institute

Identifier

• 63751
• E-project-042622-120136

Keyword

• Microneedle
• Recellularization
• Decellularization
• Deep tissue

Advisor

• Ambady, Sakthikumar

Year

• 2022

Date created

• 2022-04-26

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright