Student Work
ROLE OF SOD AND CATHEPSIN-D IN ALZHEIMER’S DISEASE Aβ CASCADE MODELS
PublicAlzheimer's disease (AD) is initiated by the formation of extracellular amyloid-B (AB) neurotoxin. Our laboratory uses neurotrophic factor (NTF) mimetics to increase neuronal survival in the presence of AB. This project investigated the potential role of cathepsin-D in AB-induced cell death, and found through fluorescence substrate assay that cathepsin-D activity increases in AB-treated human neuronal cells. We also found that NTF treatment can increase the cellular levels of therapeutic anti-oxidative superoxide dismutase in the brains of AD mice.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042711-234420
- Advisor
- Year
- 2011
- Date created
- 2011-04-27
- Resource type
- Major
- Rights statement
- License
Relations
- In Collection:
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Donahue_and_Lobdell,_MQP_Final.pdf | Public | Download |
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