Implantable Biological Pacemaker for Permanent Autonomous Pacing of the Heart
PublicElectronic pacemakers are widely used to treat cardiac pacing problems, but the devices have inherent limitations. Hyperpolarization-activated cyclic nucleotide gated (HCN) transfected human mesenchymal stem cells (hMSCs) show promise as a solution to these problems, but these cells must be contained at the implant site to preserve functionality and patient safety. This project aims to design and fabricate a device that is capable of preventing cell migration while allowing for cell-cell interactions and enabling minimally invasive delivery. A heat-sealed, micropatterned scaffold was created to achieve mechanical strength and cell retention while maintaining low thickness necessary for cell interactions. Testing suggests cells can be safely restrained during and after implantation.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042512-163416
- Advisor
- Year
- 2012
- Date created
- 2012-04-25
- Resource type
- Major
- Rights statement
Relations
- In Collection:
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Implantable_Biological_Pacemaker_for_Permanent_Autonomous_Pacing_of_the_Heart.pdf | Public | Download |
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