Type 1 and Type 2 diabetic patients experience prolonged hyperglycemia punctuated by short episodes of hypoglycemia. These patients develop diabetic complications, which involves loss of normal tissue function. Cell death via the endoplasmic reticulum (ER) stress pathway in response to nutrient availability is a potential mechanism underlying these complications. To understand glucose's role in ER stress in vivo, we induced hypo- and hyper-glycemia in zebrafish embryos, and analyzed normal development and CHOP/GADD153 expression, a major component of ER stress signaling.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Riley, Phoebe Elizabeth
• Lorenzo, Briana Christine

Contributors

• Dilorio, Philip

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042810-180321

Advisor

• Adams, David S.

Year

• 2010

Sponsor

• UMass Medical Center

Date created

• 2010-04-28

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright