The data in this MQP show that circadian rhythm and low-level irradiation of hosts affects the success of bone marrow engraftment. The optimal time of bone marrow transplant was determined through the study of circadian rhythm of the donor and host bone marrow. Sub-myeloablation of the host allowed for high levels of engraftment even when low cell doses or 5-FU treated marrow was injected. This in turn eased the data analysis because differences between groups were easier to see. The effects of circadian rhythm need to be looked into further as they offer a route to more effective bone marrow transplants.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Damon, Jeffery R.

Publisher

• Worcester Polytechnic Institute

Identifier

• 99D033M

Advisor

• Adams, David S.

Year

• 1999

Date created

• 1999-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright