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Copper Homeostasis in S. meliloti

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The Sinorhizobium meliloti genome encodes five Cu+-ATPases that aid in detoxification and regulate copper homeostasis via the efflux of copper from the cytoplasm to the periplasmic space. Bioinformatic analysis concluded that additional cuproproteins found in S. meliloti genome might interact with Cu+-ATPases to aid in copper homeostasis. Atomic Absorption Spectroscopy (AAS) was used to determine the concentration of copper in subcellular fractionation of wild type and mutant strains. Results suggest that copper distribution in different subcellular fractions is linked to the dynamic of copper transporters and cuproproteomes.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • E-project-101013-152646
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  • 2013
Date created
  • 2013-10-10
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