Student Work

Upconversion Nanoparticles For Photodynamic Therapy

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The goal of this project was to establish a noninvasive cancer therapy with minimal side effects, low cost, and specific in targeting tumor cells. The team engineered novel and biocompatible Upconversion Nanoparticles (UCNPs) with a calcium fluoride shell Ytterbium and Erbium core conjugated with a photoactive prodrug 5-Aminolevulinic Acid (ALA-UCNP). UCNPs converted near-infrared light into visible light when excited at ~980nm. Emission of the red light from the ALA-UCNPs activates ALA, causing cell death with exposure to 980nm laser light.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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Identifier
  • E-project-042214-122140
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Year
  • 2014
Sponsor
Date created
  • 2014-04-22
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Major
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Last modified
  • 2021-02-02

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