Student Work
The Importance of Actin-Interacting Proteins: DBN-1, ERM-1, PLST-1, and F38E9.5 for Pore-Forming Toxin Defense in C. elegans
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open in viewerThe Aroian lab previously identified a list of differentially regulated proteins when Caenorhabditis elegans was exposed to Cry5B. The actin-interacting proteins showed the most notable changes. Using genetic interacting assays with known pathways, hypersensitivity assays, pore repair assays, and endocytosis assays, we investigated the potential role of four actin-binding genes: dbn-1, erm1, plst-1, and F38E9.5. Knockdown of dbn-1, erm1, and plst-1 showed increased susceptibility to toxin Cry5B exposure than empty vector, suggesting these genes play a functional role in toxin defense.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-042716-175040
- Advisor
- Year
- 2016
- Sponsor
- Date created
- 2016-04-27
- Resource type
- Major
- Rights statement
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Miniaturansicht | Titel | Sichtbarkeit | Embargo Release Date | Aktionen |
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4-26-16__Tammy_Zamaitis_MQP_Final.pdf | Öffentlich | Herunterladen |
Permanent link to this page: https://digital.wpi.edu/show/4q77fs874