The mitotic spindle is responsible for mechanically moving chromosomes as the cell divides. Defects in formation and application of the mitotic spindle can lead to improper chromosome segregation, resulting in aneuploidy. Aneuploidy can interfere with essential pathways, compromise cellular fitness, or contribute to diseases like cancer. Mitotic spindle formation depends on dynein, a motor protein that walks along microtubules (MTs) to organize filaments. Cortical dynein is a subpopulation localized to the cell cortex that anchors MTs and generates pulling forces exerted on spindle MTs, aiding in spindle organization and chromosome movement. This data demonstrates that dynein motor activity antagonizes kinetochore attachments and drives chromosome movement and alignment during mitosis.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Shanks, Nora

Publisher

• Worcester Polytechnic Institute

Identifier

• 121809
• E-project-042524-160835

关键词

• Chromosome Alignment
• Microtubules
• Chromosome Segregation
• Cortical Dynein
• Cell Biology
• Mitosis

Advisor

• Manning, Amity L.

Year

• 2024

Date created

• 2024-04-25

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Source

• E-project-042524-160835

Rights statement

• In Copyright

最新修改

• 2024-05-21