Search for Cervical Stem Cells Using ImmunofluorescencePublic
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Recent models for carcinogenesis propose a strong role for stem cells and their potential for immortality. It is unclear whether cervical stem cells exist, thus their potential role in cervical cancer has not been investigated. This project used immunofluorescence microscopy to locate areas which may contain stem cells in normal human cervical tissue. Antibodies were used against known stem cell markers: ABCG2, alpha-k15, Oct-3/4, Tenascin-C, CD 133, and CD 200. The alpha-k15, and Tenascin-C data for cervical tissue versus skin controls indicate that stem cells may be present in the squamous epithelium of the cervix.
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