Three dimensional cell-derived scaffolds charged with neuronal growth factors are currently being evaluated as therapeutics for healing spinal cord injuries in rats (Total Record, Inc). To determine if specific neuronal growth factor genes are activated by the therapy, an in vitro model was developed in which cultured human SHSY neuronal cells were treated with the growth factors, and the upregulation of specific genes monitored by RT-PCR. The data indicate the therapy upregulates several genes known to promote neuronal growth.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Rogers, Jonathan Adam
• Longmire, Tyler A.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-041006-115044

Advisor

• Adams, David S.

Year

• 2006

Sponsor

• Total Record

Date created

• 2006-04-10

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright