Copper-based metal-organic framework (MOF) HKUST–1 was synthesized to further explore the possibilities of surface modifications on MOFs. Our aim is to expand our group’s prior work on MOFs’ ability to perform controlled release of small molecule guests, for the eventual goal of therapeutic drug delivery. We hypothesized that surface modifications could be implemented on HKUST–1, and that these could change the release of certain dyes. Synthesized HKUST–1 was reacted with silanes and carboxylic acids, and crystals were loaded with small molecule dyes. Crystal synthesis was supported by powder X-ray diffraction (PXRD). Surface modifications were evaluated by X-ray photoelectron spectroscopy (XPS) and in vacuo Ar+ sputtering. UV-vis spectroscopy was used to assess dye release. We have demonstrated that HKUST–1 can be capped by both carboxylic acids and silanes, and that surface modification with triphenylacetic acid can alter release of dye.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Lebak, Calyx

Publisher

• Worcester Polytechnic Institute

Identifier

• 115434
• E-project-122023-110158

Advisor

• Grimm, Ronald
• Burdette, Shawn C

Year

• 2023

Date created

• 2023-12-20

Resource type

• Major Qualifying Project

Major

• Chemistry

Source

• E-project-122023-110158

Rights statement

• In Copyright

Last modified

• 2024-02-07