HVS'S ORF12 and the Downregulation of MHC-IPublic
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K3 and K5 proteins encoded by Kaposi's sarcoma-associated herpesvirus (KSHV) downregulate major histocompatibility complex class I (MHC-I) from the surface of host cells through ubiquitin-dependent endocytosis and degradation. The closest relative to KSHV is Herpesvirus saimiri (HVS) which naturally infects squirrel monkeys. The open reading frame (Orf) 12 of HVS shows a high structural homology to K3 and K5 proteins and thus, the functionality of Orf12 to downregulate MHC was tested. It was indeed found to be capable of downregulation.
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