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Syntaxin 1A functions as the sufficient T-SNARE for spontaneous fusion of bovine NSG to a planar lipid bilayer Public

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The SNARE complex, involved in vesicular trafficking and exocytosis, is composed of proteins in the vesicular membrane (V-SNAREs) that intertwine with proteins of the target membrane (T-SNAREs). Our results show that modified bovine neurosecretory granules (NSG) were able to spontaneously fuse with a planar lipid membrane, containing the t-SNARE syntaxin 1A. This provides evidence that syntaxin alone is able to form a functional fusion complex. This project is another step towards producing an artificial synapse to study possible regulatory components affecting vesicle fusion.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
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  • 00D055M
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Year
  • 2000
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Date created
  • 2000-01-01
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