Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells.

George, Kerri L

Student Work

Ajulemic acid, a nonpsychoactive cannabinoid acid, suppresses osteoclastogenesis in mononuclear precursor cells and induces apoptosis in mature osteoclast-like cells.

Public

Ajulemic acid (AjA) is a synthetic analog of the tetrahydrocannabinol (THC) metabolite THC-11-oic acid. AjA reduces release of the inflammatory cytokine interleukin-1b (IL-1b) from peripheral blood and synovial fluid monocytes, and prevents bone degradation in a rat model of inflammatory arthritis. Because preosteoclasts are of monocyte lineage, we initiated these studies to understand the direct effects of AjA on both osteoclast differentiation and activity. In this paper, we demonstrate that AjA suppresses osteoclastogenesis in vitro in a concentration dependent manner.

This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

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