This project investigated the use of hydrophobically modified Dextran as a surfactant in oil-in-water emulsions. Studies were performed to investigate the solubility and partition coefficient of the drug, stability of the emulsion and the kinetics of drug release. The solubility was found to be 3.91g/L in water and 4.54/L in 0.039M phosphate buffer. The partition coefficient was found to be 10.6 and the emulsion proved to be stable for a period of one week but not after reconstitution. Kinetic testing provided the desired release profile.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Correia, Raul Carlos
• McElearney, Kyle Shamus
• Pinzon, Paola Andrea

Publisher

• Worcester Polytechnic Institute

Identifier

• 05D274M

Advisor

• Camesano, Terri Anne

Year

• 2005

Center

• Nancy, France Project Center - MQP

Sponsor

• University of Lorraine - National School of Chemcial Industries

Date created

• 2005-01-01

Resource type

• Major Qualifying Project

Major

• Chemical Engineering

Rights statement

• In Copyright