Previous work at Abbott Bioresearch Center on a putative chromatin-opening sequence inserted into a plasmid dubbed "genomic vector", suggested that the vector caused an increase in the rate of methotrexate-induced amplification in Chinese Hamster Ovary cells. This project supported the hypothesis that the genomic sequence may cause an increase in amplification effects; however, the increase was not statistically significant, nor was the increase in expression of antibody in CHO cells when compared to the parental vector.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Chaplin, Joanna L.

Contributors

• Ahmed, Asma

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-122007-173047

Advisor

• Adams, David S.

Year

• 2007

Sponsor

• Abbott Laboratories

Date created

• 2007-12-20

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved