THE EFFECT OF A PUTATIVE CHROMATIN-OPENING ELEMENT ON METHOTREXATE AMPLIFICATIONPublic
Downloadable Contentopen in viewer
Previous work at Abbott Bioresearch Center on a putative chromatin-opening sequence inserted into a plasmid dubbed "genomic vector", suggested that the vector caused an increase in the rate of methotrexate-induced amplification in Chinese Hamster Ovary cells. This project supported the hypothesis that the genomic sequence may cause an increase in amplification effects; however, the increase was not statistically significant, nor was the increase in expression of antibody in CHO cells when compared to the parental vector.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Date created
- Resource type
- Rights statement
- In Collection:
|Thumbnail||Title||Visibility||Embargo Release Date||Actions|
Permanent link to this page: https://digital.wpi.edu/show/8049g663v