Diabetes is a significant cause of morbidity and mortality. Poly y-glutamic acid is a promising novel slow-release drug delivery system that could improve the lives of diabetic patients. Using cultured cells, these studies examined the ability of an insulin/PGA conjugate to deliver insulin over time in culture. Protocols were also developed to determine the mechanism of insulin release from the polymer. Preliminary results suggest insulin activity persists over 72 hours following a single administration of the conjugate.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Brito, Alyssa Anne

Publisher

• Worcester Polytechnic Institute

Identifier

• 01C023M

Advisor

• Rulfs, Jill

Year

• 2001

Date created

• 2001-01-01

Resource type

• Major Qualifying Project

Major

• Biochemistry

Rights statement

• In Copyright