A mechanistic study of the inhibition of beta amyloid production by protease inhibitors in a whole cell model

Connarn, Kristin Anne

Student Work

A mechanistic study of the inhibition of beta amyloid production by protease inhibitors in a whole cell model

Public

This project examined the mechanisms responsible for the inhibition of beta-amyloid production by protease inhibitors in a whole cell model. Dose-dependency curves were created for eight potent protease inhibitors and the inhibition patterns for both A1-40 and A1-42 were studied. Results indicated that a single -secretase was responsible for the cleavage of A and the project revealed eight potential leads in the AstraZeneca drug screening project.

This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

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