A report from the CDC published a “watch list” of antimicrobial resistant “super-bugs”. Fluconazole-resistant Candida was the only fungal species identified as a serious health threat. More recently, C. auris is emerging as a multidrug-resistant fungal pathogen with high mortality rates. C. auris is often resistant to all classes of antifungal drugs and tends to occur in hospitalized patients with the same risk factors as infection by any Candida spp. This has prompted the CDC to issue a call-to-action to “better understand, contain and stop the spread of this drug-resistant fungus”. Here we use C. elegans as a model host to measure the virulence of clinical isolates of C. auris, C. tropicalis, C. dubliniensis, C. lusitaniae, and C. krusei as compared to a reference strain C. albicans.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Lambert, Brittney
• Fabrizio, Natalie
• Murphy-Cook, Nina Adele

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042518-214834

Advisor

• Rao, Reeta Prusty

Year

• 2018

Date created

• 2018-04-25

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright