Student Work
An Examination of the Potential of Porcine Mitral Valvular Interstitial Cell Dedifferention by Alpha Smooth Muscle Actin Expression and Caspase activity
PublicThe aim of this study was to determine whether the apparent reduction in cell number and alpha-SMA expression of porcine mitral valvular interstitial cells plated on substrates of varying stiffness was due to apoptosis or dedifferentiation. This decrease was determined to be a result of apoptosis as indicated by caspase levels comparable to the positive control. A more thorough investigation into cellular communication and signaling will be invaluable to the development of next generation valve replacements.
- This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
- Creator
- Publisher
- Identifier
- E-project-121206-175535
- Advisor
- Year
- 2006
- Date created
- 2006-12-12
- Resource type
- Major
- Rights statement
- License
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