An Examination of the Potential of Porcine Mitral Valvular Interstitial Cell Dedifferention by Alpha Smooth Muscle Actin Expression and Caspase activityPublic
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The aim of this study was to determine whether the apparent reduction in cell number and alpha-SMA expression of porcine mitral valvular interstitial cells plated on substrates of varying stiffness was due to apoptosis or dedifferentiation. This decrease was determined to be a result of apoptosis as indicated by caspase levels comparable to the positive control. A more thorough investigation into cellular communication and signaling will be invaluable to the development of next generation valve replacements.
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