The material properties of cancellous bone are often adversely affected by degenerative bone diseases, such as osteoporosis. Quantification of elastic modulus and intrinsic permeability provides an understanding of the tissue's biphasic structure-function relationship. The goal of this project was to design a fixture and protocol using Darcy's Law to measure the triaxial permeability of cancellous bone. Experiments revealed the anisotropic and heterogeneous nature of bone. The resulting methodology presented accommodates future investigation of the relationship between tissue deformation and permeability.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Schlichting, Alyssa Lee
• Wilson, Christopher Garrison
• Upton, Maureen Lacey

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D097M

Advisor

• Kohles, Sean S.
• Bonassar, Lawrence J.

Year

• 2000

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright