Ependymin is a vertebrate neurotrophic factor. Its presence has been confirmed in the horseshoe crab, Limulus polyphemus, (Barroso 1999) but its role in this animal is unknown. Experiments were performed to determine if ependymin is involved in limb regeneration for Limulus. Legs were removed from horseshoe crabs in various stages of development and the subjects were treated with either rabbit anti-ependymin (SHEILA) or a control substance. The larval and post-larval subjects did not exhibit a great deal of difference between the treatment and control groups. The two- and three-year juvenile subjects, however, indicated that anti-ependymin treatment is correlated with slower regeneration.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Vallee, Lisa C.

Publisher

• Worcester Polytechnic Institute

Identifier

• 00D155M

Advisor

• Gibson, Daniel G.

Year

• 2000

Date created

• 2000-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved