Correlation analysis is a tool commonly used to obtain information about the dynamics of biofilaments such as actin and microtubules in cells. This approach is particularly useful when individual identification of filaments is difficult in vivo. The goal of this project is to develop a coarse-grained model of dynamic actin filaments using Brownian dynamics simu- lations, and to validate correlation analysis as a viable technique to measure the dynamics, and determine its range of applicability. Particular focus is on the dependence on the density of filaments, as well as polymerization and depolymerization.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Vandal, Steven Robert

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042513-154900

Advisor

• Tuzel, Erkan
• Vidali, Luis

Year

• 2013

Date created

• 2013-04-25

Resource type

• Major Qualifying Project

Major

• Physics

Rights statement

• In Copyright