The Role of Beta-Cell Apoptosis in Diabetes Pathogenesis in Biobreeding/Worcester Diabetes Prone RatsPublic
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The purpose of this project was to correlate the time of onset of pancreatic a-cell apoptosis with the onset of diabetes in the BioBreeding Diabetes Prone (BB/DP) rat model to provide an initial determination of whether apoptosis is a primary or secondary event in the disease onset. Immunofluorescence microscopy was used to assay the appearance of Annexin-V apoptotic protein marker and the appearance of DNA fragmentation (via TUNEL assays). Due to time constraints, confirmation of beta-cell apoptosis was not possible in this study; future research, however, should conclusively prove the role of beta-cell apoptosis in diabetes onset.
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