The Role of SUB1 in the Repair of UV Induced DNA Damage in Saccharomyces cerevisiaePublic
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Understanding the mechanisms involved in DNA repair is an important step in understanding and possibly controlling numerous human diseases. Previously the S. cerevisiae gene SUB1 and its human ortholog PC4 have been shown to play an important role in the repair of DNA lesions resulting from oxidative stress. In this project, I demonstrate that sub1 deletion mutants do not show an increase in UV sensitivity, however, in strains with combinations of other repair genes knocked out, the addition of the sub1 deletion does result in increased UV sensitivity.
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