Understanding the mechanisms involved in DNA repair is an important step in understanding and possibly controlling numerous human diseases. Previously the S. cerevisiae gene SUB1 and its human ortholog PC4 have been shown to play an important role in the repair of DNA lesions resulting from oxidative stress. In this project, I demonstrate that sub1 deletion mutants do not show an increase in UV sensitivity, however, in strains with combinations of other repair genes knocked out, the addition of the sub1 deletion does result in increased UV sensitivity.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Worcester MA

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042306-143701

Advisor

• Adams, David S.

Year

• 2006

Sponsor

• UMass Medical School

Date created

• 2006-04-23

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright