Genes that are involved in localization or modulation of neurotransmitter receptors are difficult to identify. We generated a C. elegans strain expressing a mutated, hyperactivitied acetylcholine receptor. These animals display a dramatic movement phenotype, as well as mislocalization of a related receptor. Our genetic screen for suppressors of the movement phenotype isolated 15 suppressors, many of which would not have been isolated using traditional methods. We believe that this strategy will find novel factors that play important roles in cholinergic signaling.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Climer, Jason Robert

Contributors

• Michael Francis

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042810-025628

Advisor

• Ryder, Elizabeth F.

Year

• 2010

Sponsor

• Umass Medical Center

Date created

• 2010-04-28

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

License

• All rights reserved

Last modified

• 2021-02-02