C. elegans Mutants with Decreased Pathogenic Response to YeastPublic
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One of the largest problems in medicine today is fungal pathogenesis. The eukaryotic nature of fungi is similar to their hosts, which include humans. Due to these similarities it is difficult to develop novel drugs against their infection. Through the development of a host-pathogen system, host factors involved in resistance may be identified. Saccharomyces cerevisiae causes a pathogenic response in wild type Caenorhabditis elegans, characterized as swelling of the anal region of the organisms. We developed an assay to test the immune response of mutant strains of C. elegans. Eight out of thirteen mutant strains displayed a deformed anal region (Dar) on the fourth day of the assay. One mutant strains, bus-4, had no visible pathogenic response to the S. cerevisiae.
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