Student Work

Torque Teno Virus: Exploring the Effects of Localization on the Apoptotic Ability of TTV-VP3

Pubblico

Contenuto scaricabile

open in viewer

In 2016, cancer is expected to take more than 1,500 lives a day. Human Torque Teno Virus third viral protein (TTV-VP3) has been shown to induce apoptosis in cancer cells while leaving primary cells unharmed. To design a cancer therapy modeled after TTV- VP3, it is necessary to research its properties. The steady-state localization of TTV-VP3 has been shown to favor the cytoplasm. It is suspected that Leu35 and Leu36 are located in the putative NES that interacts with CRM1. Site-directed mutagenesis was performed to mutate these Leucines to Threonines in an attempt to hinder its export capabilities, and drive the steady-state levels of TTV-VP3 to the nucleus. It was determined that Leu35 and Leu36 are not essential for nuclear export but are essential for apoptosis induction.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042816-133600
Advisor
Year
  • 2016
Date created
  • 2016-04-28
Resource type
Major
Rights statement

Relazioni

In Collection:

Articoli

Elementi

Permanent link to this page: https://digital.wpi.edu/show/fx719p02d