Prostaglandins are medically interesting because of the wide variety of roles they play in the body. This project draws upon previous research on the total synthesis of a prostaglandin skeleton via a noncyclic precursor. The focus of this research is optimization: by finding a facile route to an important chiral acetylenic ester intermediate, the total synthesis can be improved. Kinetic resolution of the key ester via a lipase isolated from Candida antarctica is explored.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• White, Rachael A.

Publisher

• Worcester Polytechnic Institute

Identifier

• 04D263M

Advisor

• Dittami, James P.

Year

• 2004

Date created

• 2004-01-01

Resource type

• Major Qualifying Project

Major

• Chemistry

Rights statement

• In Copyright