Glioblastoma Multiforme (GBM) continues to be a leading form of malignant brain cancer. GBM presents a high variability patient to patient. This provides a need for a theranostic system capable of both delivering therapeutic and in real-time visually observe results. Current methods involve months between treatment application and available results. Based on Nemucore Medical Innovation’s drug delivery vehicles, nanoemulsions (NE) containing chemotherapeutics are being utilized to target cancer cells and reduce systemic toxicity. Through the automation of required statistical analysis and creation of a wire-frame rat brain model with 174 defined brain regions a software capable of providing ‘real-time’ pharmacodynamics analysis of Gd3+ annotated, receptor-targeted NE is one step closer.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Sadraei, Atieh
• Lacarra, Elizabeth Denise
• Day, Michael Raymond
• Sacks, Jessica Meredith

Contributors

• Patel, Niravkumar

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-043015-050001

Advisor

• Flaherty, Patrick J.

Year

• 2015

Sponsor

• Nemucore

Date created

• 2015-04-30

Resource type

• Major Qualifying Project

Major

• Biomedical Engineering

Rights statement

• In Copyright