CAN A MORRIS WATER MAZE TEST DISTINGUISH ALZHEIMER’S MICE FROM WT MICE?Public
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Alzheimer’s disease (AD) is a neurodegenerative disease caused by the accumulation of amyloid-beta in the brain. The purpose of this MQP is to develop a procedure for performing the Morris water swimming test in-house at WPI, and determine whether this test can distinguish WT from AD behavior at 4 months of age. The data indicate that at 4 months of age, this AD strain is indistinguishable from WT mice in the Morris test. In preparation for future in vivo tests with various neurotrophic factor peptides (which our laboratory has shown to restore neuronal survival), we compared the activity of several amyloid-beta batches on human neuronal cell morphology, and conclude that all amyloid-beta batches induced significant morphological alterations relative to untreated control cultures.
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