Mutations in the C. elegans gene srf-6 result in the constitutive display of a surface antigen normally displayed only in the L1 developmental stage. To determine the location of these mutations, an extensive DNA sequence analysis of a candidate gene region, previously shown to partially rescue srf-6, was undertaken for each of 8 identified mutants. An additional mutant, produced by transposon insertion, was stabilized by back-crossing. Finally, a transcriptional analysis was performed to determine the exon/intron pattern of the candidate gene.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Wolfe, Devin Michael

Publisher

• Worcester Polytechnic Institute

Identifier

• 03D152M

Advisor

• Politz, Samuel M.

Year

• 2003

Date created

• 2003-01-01

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright