This study investigated the effects of 2,3-dihydroxybenzoic acid (DHB) on the growth of E. coli in the presence of antibiotics with different mechanisms of action. DHB is a natural metabolite found in certain plants and a minor by-product of human aspirin metabolism. Results showed that E. coli treated with DHB exhibited resistance to vancomycin, tetracycline, and nalidixic acid, suggesting that DHB may have potential implications for induced antibiotic resistance. Further research is needed to determine the antibiotics affected and explore the potential therapeutic applications of metabolites.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Littlefield, Dana
• Zhu, Tammie

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042723-151940
• 106451

Keyword

• 2,3-dihydroxybenzoate
• E. coli
• Antibiotic Resistance
• Metabolites
• Bacteria
• 2,3-dihydroxybenzoic acid

Advisor

• Buckholt, Michael Allan

Year

• 2023

Date created

• 2023-04-27

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology
• Biotechnology

Source

• E-project-042723-151940

Rights statement

• In Copyright

Last modified

• 2023-06-23