Antibiotic-resistant bacteria and chronic wound infections pose a serious threat to patient health and overall quality of life. The goal of this project was to determine the action mechanism of fCBD-LL37 against phosphatidylcholine lipid bilayer using a quartz crystal microbalance with dissipation. At increased concentrations, fCBD interacted to a greater extent with the lipid bilayer indicating that the tethered fCBD-LL37 shows greater peptide bondage to bilayer. This is the foundation of the development of bipolymer-tethered AMPs for wound healing applications.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Smith, Rachel E
• Lee, Yoon Kyong

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-042717-111659

Advisor

• Camesano, Terri Anne

Year

• 2017

Date created

• 2017-04-27

Resource type

• Major Qualifying Project

Major

• Chemical Engineering

Rights statement

• In Copyright