Student Work

Analyzing the dysfunction of profilin1 in ALS

Public

Downloadable Content

open in viewer

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease which affects motor neurons in the brain and spinal cord. This project analyzed the ALS-associated protein, profilin 1 (PFN1). Multiple experiments were completed in order to analyze what occurs when profilin is not functioning correctly. Cloning, transfection, creating knockdown lines, and observing cells using fluorescent imaging where among the tools used to analyze wildtype PFN1 and ALS-mutant PFN1.

  • This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.
Creator
Publisher
Identifier
  • E-project-042516-123240
Advisor
Year
  • 2016
Sponsor
Date created
  • 2016-04-25
Resource type
Major
Rights statement

Relations

In Collection:

Items

Items

Permanent link to this page: https://digital.wpi.edu/show/js956h21n