Promensil is an over-the-counter phytoestrogen supplement marketed to menopausal women as an alternative to hormone replacement therapy. Prior studies looking into the relationship between Promensil and breast cancer have yielded inconsistent results, so the goal of this study was to investigate the relationship between Promensil and cell proliferation in an estrogen receptor-positive breast epithelial cell line. It was found that introducing Promensil to T47D cells correlated to decreased cell counts, and markers for the cell cycle, DNA replication, and apoptosis were followed to investigate the mechanism behind this decrease. Future studies should investigate the receptor status of the triple negative control line used and should explore the protein expression in this line as well.

• This report represents the work of one or more WPI undergraduate students submitted to the faculty as evidence of completion of a degree requirement. WPI routinely publishes these reports on its website without editorial or peer review.

Creator

• Huber, Sarah R.

Publisher

• Worcester Polytechnic Institute

Identifier

• E-project-050221-182016
• 21201

Advisor

• Buckholt, Michael Allan
• Rulfs, Jill

Year

• 2021

Date created

• 2021-05-02

Resource type

• Major Qualifying Project

Major

• Biology & Biotechnology

Rights statement

• In Copyright

Last modified

• 2021-08-28